Spravato® Therapy in Wilmington, Delaware

Therapeutic Infusions is proud to offer Spravato®—a groundbreaking, self-administered nasal spray. As the only FDA-approved psychedelic treatment for depression, Spravato® represents a significant advancement in mental health care and is now eligible for insurance coverage. Explore how Spravato® treatments at Therapeutic Infusions can provide you with a new path to well-being. Discover why our compassionate approach and expert care make us the ideal choice for your treatment journey. Contact us today to learn more and see if Spravato® is right for you.

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What is Spravato?

Spravato® (esketamine) is an FDA-approved nasal spray used alongside oral antidepressants to treat adults with treatment-resistant depression. It contains esketamine, a more potent form of ketamine, which works by targeting the NMDA receptors in the brain, leading to rapid and significant improvements in mood and depressive symptoms. Administered under medical supervision in a healthcare setting, Spravato requires close post-treatment monitoring due to potential side effects. It offers a novel treatment option for those who haven't found relief with other depression therapies.

Benefits of Spravato 

Potential benefits of Spravato (esketamine) treatment include:

  • Rapid reduction in depressive symptoms. 

  • Effectiveness in treatment-resistant depression.

  • Improvement in mood and emotional well-being.

  • Potential reduction in suicidal thoughts in specific cases.

  • Quick onset of action compared to traditional antidepressants. 

  • Provides an alternative for those who haven't responded to other treatments.
  • FDA approval makes the treatment eligible for insurance coverage.

 Understanding Treatment-Resistant Depression

Treatment-resistant depression (TRD) is a form of major depressive disorder (MDD) that doesn't respond to traditional antidepressant medications. Patients with TRD often experience persistent, debilitating symptoms despite trying multiple treatments. Spravato is a relatively new and exciting treatment option that can offer hope in such cases. Spravato, administered as a nasal spray, works differently from conventional antidepressants by targeting the NMDA receptors in the brain. This can result in a rapid improvement in depressive symptoms, even in those who have struggled with TRD. It's a promising option for individuals seeking relief from the profound impact of chronic, unresponsive depression.

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How Spravato Works

Spravato (esketamine) is administered via a nasal spray, entering the brain through the olfactory bulbs and targeting the N-methyl-D-aspartate (NMDA) receptor, a key player in mood and thought regulation. Unlike traditional antidepressants that focus on the serotonin system, esketamine acts on the NMDA receptors, leading to rapid improvement in depressive symptoms, particularly for those with treatment-resistant depression (TRD).

Spravato affects neurons that use glutamate to communicate, specifically acting at the synapse. GABA neurons, which inhibit glutamate neurons, may cause traditional antidepressants to fail for some TRD patients. Spravato is believed to block the NMDA receptor on GABA neurons, allowing the release of glutamate. This, in turn, stimulates AMPA receptors on receiving neurons, causing calcium influx and the release of brain-derived neurotrophic factor (BDNF). BDNF promotes neuronal growth and strengthens connections, offering a potential explanation for Spravato's unique ability to help patients move past depressive patterns of thought and feeling.

What Does Spravato Treatment Look Like?

Preparing for Treatment

All patients will undergo a thorough medical history review and screening to ensure safety and efficacy before starting treatment. Once approved, you will receive detailed instructions tailored to your needs. Generally, to prepare for your session, avoid eating for 6 hours and drinking liquids for 2 hours before your appointment. Follow all medication instructions provided, taking or skipping them as directed on the day of your treatment. Refrain from using cannabis on the day of your session and limit alcohol consumption beforehand. Arrange for transportation home, as driving is not recommended due to possible side effects like dizziness. For your comfort, bring a blanket if you prefer your own, headphones, and a good playlist, as music plays a crucial role in the experience. Wear loose-fitting clothing and try to avoid stressful situations prior to your treatment.

On Treatment Day

On treatment day, you will be welcomed into a comfortable, designated treatment room. Our rooms feature medical-grade recliners, adjustable colored/moving lights, books, and a video screen. You will self-administer the nasal spray under the close supervision of our healthcare professionals. We monitor you for at least two hours to ensure your safety and address any potential side effects. We provide blankets, a pillow, and noise-cancelling headphones to help create a relaxing environment during your session.


After your session, we continue to monitor you until you are stable and ready to leave. It's important to have pre-arranged transportation, as you should not drive or operate heavy machinery for the rest of the day. Most patients can return to work or normal activities the following day. The treatment schedule typically starts with twice-weekly sessions for the first four weeks, then once-weekly sessions for the next month. Afterward, the frequency may be reduced to once every one to two weeks, based on your response and progress. Regular follow-up appointments will help us monitor your progress and adjust your treatment plan as necessary.

What does Spravato feel like?

Patients undergoing Spravato treatment often report a range of sensations during and after the administration. Common experiences include a feeling of dissociation or detachment from reality, mild sedation, and a sense of relaxation. Some patients describe a floating sensation or a dreamlike state. These effects typically begin within minutes of using the nasal spray and can last for up to two hours. Other possible sensations include dizziness, nausea, and a temporary increase in blood pressure. It's important to note that these experiences vary from person to person and are closely monitored by our medical staff during the treatment session to ensure safety and comfort.

Who Should Take Spravato

Spravato is intended for adults with treatment-resistant depression or major depressive disorder with acute suicidal ideation or behavior. Patient eligibility is determined through a comprehensive assessment by a healthcare provider, considering factors like medical history, response to prior depression treatments, and current mental health status. It's crucial that patients have tried other antidepressants without adequate improvement before considering Spravato.

Therapeutic Infusions Amenities

Private Rooms: We offer private infusion rooms to ensure comfort and privacy.

Medical Recliners: Our rooms are equipped with comfortable medical recliners.

Dimming Lights: We provide dimming lights in each room to ease light sensitivity.

Total Comfort:  We provide everything for your comfort during your treatment, including a pillow, blankets, eye masks, and noise cancelling headphones.

Monitoring by Trained Professionals: Our staff includes trained medical professionals who monitor patients throughout the infusion process.

Side Effects and Safety Measures

Spravato can cause side effects like:

  • Dissociation
  • Dizziness
  • Nausea
  • Sedation
  • Increased blood pressure
  • Headache

Due to these risks, it's administered in a healthcare setting with post-treatment observation. 

  • Post-treatment observation
  • Avoid driving or operating heavy machinery on treatment day
  • Review of medical history and current medications
  • Individualized treatment planning

Spravato vs. Ketamine

Spravato (esketamine) is a nasal spray form of ketamine, specifically the S-enantiomer of ketamine. While both are used in depression treatment, Spravato is FDA-approved for treatment-resistant depression and requires medical supervision. Ketamine, often used off-label for depression, is administered as an infusion or injection. Spravato's nasal spray form allows for easier administration but still requires healthcare setting due to potential side effects. Both can provide rapid relief from depressive symptoms but have different regulatory statuses and administration methods.

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Safety first!

Full Crash Cart

We prioritize the safety and comfort of our Spravato patients, offering a full "crash-cart" on-site. This ensures immediate response to any medical needs, enhancing the treatment experience with an added layer of security and care.

Medical Grade Recliners

Our patients can experience unparalleled comfort with our medical-grade recliners. These recliners are designed to provide optimal support and relaxation, ensuring a serene and comfortable environment during treatment sessions.

Medical doctor in house

Our Spravato Treatments are administered with a fully trained and licensed medical doctor on-site. This guarantees immediate, expert medical attention in the rare event of an emergency, providing patients with an extra layer of security and peace of mind. All clinical staff is ACLS (Advanced Cartiac Life Support) certified. 

Private & Secure Supervision

Every Spravato treatment session is supervised throughout its entire duration, ensuring a secure and private experience. This approach is vital for maintaining comfort and enhancing the therapeutic efficacy of the treatment, providing patients with a safe, controlled environment for optimal care.


Changing lives and improving health


Jeanne-Marie Raziano, DMin, DDiv
Educated at Columbia, Penn and post-grad certifications from Harvard, Stanford & Rutgers.
Jeanne-Marie Raziano, DMin, DDiv
Jeanne-Marie Raziano, DMin, DDiv
Educated at Columbia, Penn and post-grad certifications from Harvard, Stanford & Rutgers. She has obtained her doctorate in ministry science as well as degrees in laboratory science, biology, and psychology. Jeanne-Marie has studied in molecular neuropharmacology, psychedelic therapy. She strives to bridge the gap between science and spirituality to help patients live healthier, more balanced lives. A life-long student of science, psychology, and spirituality to provide the best care possible. Jeanne-Marie is dedicated to creating a space of understanding and support for those dealing with crisis, trauma, and mental health issues. Offering counseling services and hosting support groups for LGBTQIA+ and survivors of childhood sexual abuse.
Joseph Raziano, MD
Medical Director
Dr. Raziano is a physician specializing in Emergency Medicine with an M.D. from Tulane University School of Medicine. Dr. Raziano is a critical care emergency physician. 
Joseph Raziano, MD
Joseph Raziano, MD
Dr. Raziano is a physician specializing in Emergency Medicine with an M.D. from Tulane University School of Medicine and a B.S. in Microbiology and Immunology from the University of Miami. He completed his residency at Emory University School of Medicine. Dr. Raziano is a board-certified and licensed physician in 8 states with more than 25 years of experience. He is helping people achieve their optimal health and well-being through cognitive and physical transformation. He is certified in Ketamine Therapy and IV Nutritional Therapy.

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Don’t wait, the start to a happier you starts today.

Spravato Frequently Asked Questions

What is Spravato?
Spravato (esketamine) is an FDA-approved nasal spray for treatment-resistant depression. Administered under medical supervision, it contains esketamine, a potent form of ketamine that targets NMDA receptors in the brain. This treatment works quickly to improve mood and reduce depressive symptoms, often in patients who haven't responded to other antidepressants. Spravato is typically used alongside an oral antidepressant for optimal results.
How does Spravato work?
Spravato works by targeting NMDA receptors in the brain, which is a different mechanism from most traditional antidepressants that target serotonin, dopamine, or norepinephrine. This unique approach can help individuals who have not responded to other depression treatments.
Who can use Spravato?
Spravato is generally prescribed for adults with treatment-resistant depression. Patients should have tried at least two other antidepressant treatments without success before considering Spravato. A healthcare provider will assess if Spravato is suitable for a patient.
How is Spravato administered?
Spravato is self-administered as a nasal spray under the supervision of a healthcare professional in a certified treatment center. It is not a medication that patients can take at home.
Are there any side effects of Spravato?
Yes, Spravato can have side effects, including dizziness, nausea, sedation, increased blood pressure, and dissociation. It’s important to discuss the potential risks and side effects with a healthcare provider.
How long does it take for Spravato to work?
Patients often begin to notice the effects of Spravato within hours to days after administration. While individual responses can vary, many report significant improvements in mood and reduction of depressive symptoms within the first two weeks of treatment. The initial phase typically involves twice-weekly sessions, during which the therapeutic effects build progressively. Continued improvement is generally observed with ongoing sessions as part of the maintenance phase. For optimal results, it is crucial to follow the prescribed treatment plan and consult with your healthcare provider throughout the process.
Is Spravato covered by insurance?
Yes, Spravato is often covered by insurance. As an FDA-approved treatment for depression, many insurance plans provide coverage for Spravato, though the extent of coverage can vary. It's essential to check with your insurance provider to understand your specific benefits and any potential out-of-pocket costs. Our clinic can assist with insurance verification and provide guidance on how to navigate the approval process to ensure you receive the necessary coverage for your treatment.
Can Spravato be used in conjunction with other antidepressants?
Yes, Spravato is typically used in conjunction with an oral antidepressant. Your healthcare provider will advise you on the best treatment combination based on your specific needs and medical history.
Do I need to make any special preparations before receiving Spravato treatment?
Patients are usually advised to avoid eating for at least 2 hours and avoid drinking liquids at least 30 minutes before treatment. It's important to follow the specific instructions given by the healthcare provider.
How is Spravato different from Ketamine?
Spravato (esketamine) and ketamine are both used for treating depression but differ significantly in their composition and administration. Spravato is a nasal spray containing esketamine, a more potent enantiomer of ketamine, and is FDA-approved specifically for treatment-resistant depression. It is administered under medical supervision in a clinic, requiring monitoring due to potential side effects. Ketamine, in contrast, is administered intravenously or intramuscularly, often in higher doses for anesthetic purposes, and is used off-label for depression. While both offer rapid relief from depressive symptoms, Spravato's formulation and delivery method are designed to enhance safety and efficacy for psychiatric use.
What feedback do your patients provide about their relief?
Our patients consistently report significant improvements in their overall well-being following treatment. Many experience a notable lift in mood, increased energy, and enhanced motivation, which allows them to reengage with daily activities and enjoy life more fully. They often describe a return of hope and a renewed ability to feel joy. Suicidal thoughts, if present, tend to decrease or resolve entirely. Additionally, patients frequently mention reduced anxiety and feeling less triggered by past traumas. This therapeutic journey often helps them forgive past hurts and leads to a decrease in irritability, contributing to a more balanced and positive emotional state.
Can you get addicted to Spravato?
SPRAVATO® has not been found to cause addiction. Clinical studies and patient reports have not indicated any potential for dependency, making it a safe option for treating depression under medical supervision.
How do I prepare for my session?
To prepare for your session, avoid eating for 6 hours and drinking liquids for 2 hours before your appointment. Follow instructions regarding medications, taking or skipping them as directed on the day of your treatment. Refrain from using cannabis on the day of your session and limit alcohol consumption beforehand. Arrange for transportation home, as you should not drive yourself. Bring a blanket if you prefer your own, headphones, and a good playlist, as music plays a crucial role in the experience. Wear loose-fitting clothing for comfort, and try to avoid stressful situations prior to your treatment.
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