Spravato for Depression Treatment in Delaware

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About Spravato

Spravato (esketamine) is an FDA-approved nasal spray used alongside oral antidepressants to treat adults with treatment-resistant depression. It targets NMDA receptors in the brain, differentiating it from traditional antidepressants. Administered under medical supervision in a healthcare setting, Spravato requires close post-treatment monitoring due to potential side effects. It offers a novel treatment option for those who haven't found relief with other depression therapies.

Benefits of Spravato 

Potential benefits of Spravato (esketamine) treatment include:

  • Rapid reduction in depressive symptoms.

  • Effectiveness in treatment-resistant depression.

  • Improvement in mood and emotional well-being.

  • Potential reduction in suicidal thoughts in specific cases.

  • Quick onset of action compared to traditional antidepressants.

  • Provides an alternative for those who haven't responded to other treatments.

 Understanding Treatment-Resistant Depression

Treatment-resistant depression (TRD) is a form of major depressive disorder (MDD) that doesn't respond to traditional antidepressant medications. Patients with TRD often experience persistent, debilitating symptoms despite trying multiple treatments. Spravato is a relatively new and exciting treatment option that can offer hope in such cases. Spravato, administered as a nasal spray, works differently from conventional antidepressants by targeting the NMDA receptors in the brain. This can result in a rapid improvement in depressive symptoms, even in those who have struggled with TRD. It's a promising option for individuals seeking relief from the profound impact of chronic, unresponsive depression.

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How Spravato Works

Spravato (esketamine) works by targeting the N-methyl-D-aspartate (NMDA) receptor, a key player in the regulation of mood and thought patterns. Unlike traditional antidepressants that focus on the serotonin system, esketamine's action on NMDA receptors can lead to a rapid improvement in depressive symptoms. This makes it particularly effective for those with treatment-resistant depression, offering new hope and a different approach to managing severe and persistent depressive symptoms.

Spravato Treatment Process

Preparing for Treatment

All of our patients will go through extensive medical history review and screening before treatment to ensure safety and efficacy. You will be provided with detailed instructions when you are approved, but in general, patients are advised to avoid eating for at least 2 hours and drinking liquids for at least 30 minutes before treatment. You should arrange for a ride home ahead of time, as driving is not recommended post-treatment due to possible side effects like dizziness.

What to Expect

A treatment session with esketamine (Spravato) typically involves nasal self-administration of the drug in a supervised healthcare setting. The patient remains under observation for about 2 hours post-treatment to monitor for side effects like dizziness or disorientation. The frequency of treatment varies, generally starting with twice-weekly sessions and potentially adjusting based on the patient's response. Patients can expect close monitoring by healthcare professionals throughout the process to ensure safety and efficacy.

Who Should Take Spravato

Spravato is intended for adults with treatment-resistant depression or major depressive disorder with acute suicidal ideation or behavior. Patient eligibility is determined through a comprehensive assessment by a healthcare provider, considering factors like medical history, response to prior depression treatments, and current mental health status. It's crucial that patients have tried other antidepressants without adequate improvement before considering Spravato.

Side Effects and Safety Measures

Spravato can cause side effects like:

  • Dissociation
  • Dizziness
  • Nausea
  • Sedation
  • Increased blood pressure
  • Headache

Due to these risks, it's administered in a healthcare setting with post-treatment observation. 

  • Post-treatment observation
  • Avoid driving or operating heavy machinery on treatment day
  • Review of medical history and current medications
  • Individualized treatment planning

Therapeutic Infusions Amenities

Private Rooms: We offer private infusion rooms to ensure comfort and privacy.

Medical Recliners: Our rooms are equipped with comfortable medical recliners.

Dimming Lights: We provide dimming lights in each room to ease light sensitivity.

Total Comfort:  We provide everything for your comfort during your treatment, including a pillow, blankets, eye masks, and noise cancelling headphones.

Monitoring by Trained Professionals: Our staff includes trained medical professionals who monitor patients throughout the infusion process.

Spravato vs. Ketamine

Spravato (esketamine) is a nasal spray form of ketamine, specifically the S-enantiomer of ketamine. While both are used in depression treatment, Spravato is FDA-approved for treatment-resistant depression and requires medical supervision. Ketamine, often used off-label for depression, is administered as an infusion or injection. Spravato's nasal spray form allows for easier administration but still requires healthcare setting due to potential side effects. Both can provide rapid relief from depressive symptoms but have different regulatory statuses and administration methods.

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Don’t wait, the start to a happier you starts today.

Safety first!

Full Crash Cart

We prioritize the safety and comfort of our Spravato patients, offering a full "crash-cart" on-site. This ensures immediate response to any medical needs, enhancing the treatment experience with an added layer of security and care.

Medical Grade Recliners

Our patients can experience unparalleled comfort with our medical-grade recliners. These recliners are designed to provide optimal support and relaxation, ensuring a serene and comfortable environment during treatment sessions.

Medical doctor in house

Our Spravato Treatments are administered with a fully trained and licensed medical doctor on-site. This guarantees immediate, expert medical attention in the rare event of an emergency, providing patients with an extra layer of security and peace of mind. All clinical staff is ACLS (Advanced Cartiac Life Support) certified. 

Private & Secure Supervision

Every Spravato treatment session is supervised throughout its entire duration, ensuring a secure and private experience. This approach is vital for maintaining comfort and enhancing the therapeutic efficacy of the treatment, providing patients with a safe, controlled environment for optimal care.


Changing lives and improving health


Jeanne-Marie Raziano, DMin, DDiv
Educated at Columbia, Penn and post-grad certifications from Harvard, Stanford & Rutgers.
Jeanne-Marie Raziano, DMin, DDiv
Jeanne-Marie Raziano, DMin, DDiv
Educated at Columbia, Penn and post-grad certifications from Harvard, Stanford & Rutgers. She has obtained her doctorate in ministry science as well as degrees in laboratory science, biology, and psychology. Jeanne-Marie has studied in molecular neuropharmacology, psychedelic therapy. She strives to bridge the gap between science and spirituality to help patients live healthier, more balanced lives. A life-long student of science, psychology, and spirituality to provide the best care possible. Jeanne-Marie is dedicated to creating a space of understanding and support for those dealing with crisis, trauma, and mental health issues. Offering counseling services and hosting support groups for LGBTQIA+ and survivors of childhood sexual abuse.
Joseph Raziano, MD
Medical Director
Dr. Raziano is a physician specializing in Emergency Medicine with an M.D. from Tulane University School of Medicine. Dr. Raziano is a critical care emergency physician. 
Joseph Raziano, MD
Joseph Raziano, MD
Dr. Raziano is a physician specializing in Emergency Medicine with an M.D. from Tulane University School of Medicine and a B.S. in Microbiology and Immunology from the University of Miami. He completed his residency at Emory University School of Medicine. Dr. Raziano is a board-certified and licensed physician in 8 states with more than 25 years of experience. He is helping people achieve their optimal health and well-being through cognitive and physical transformation. He is certified in Ketamine Therapy and IV Nutritional Therapy.

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Don’t wait, the start to a happier you starts today.

Spravato Frequently Asked Questions

What is Spravato?
Spravato, known generically as esketamine, is a nasal spray medication used for treating depression. It's particularly used in cases of treatment-resistant depression and is often prescribed alongside an oral antidepressant.
How does Spravato work?
Spravato works by targeting NMDA receptors in the brain, which is a different mechanism from most traditional antidepressants that target serotonin or norepinephrine. This unique approach can help individuals who have not responded to other depression treatments.
Who can use Spravato?
Spravato is generally prescribed for adults with treatment-resistant depression. Patients should have tried at least two other antidepressant treatments without success before considering Spravato. A healthcare provider will assess if Spravato is suitable for a patient.
How is Spravato administered?
Spravato is self-administered as a nasal spray under the supervision of a healthcare professional in a certified treatment center. It is not a medication that patients can take at home.
Are there any side effects of Spravato?
Yes, Spravato can have side effects, including dizziness, nausea, sedation, increased blood pressure, and dissociation. It’s important to discuss the potential risks and side effects with a healthcare provider.
How long does it take for Spravato to work?
Some patients may start to see improvements in their symptoms within the first few weeks of treatment. However, it varies from person to person, and some may require a longer period to notice significant changes.
Is Spravato covered by insurance?
Coverage for Spravato varies depending on the insurance plan. It's advisable to check with your insurance provider to understand the coverage and costs associated with Spravato treatment.
Can Spravato be used in conjunction with other antidepressants?
Yes, Spravato is typically used in conjunction with an oral antidepressant. Your healthcare provider will advise you on the best treatment combination based on your specific needs and medical history.
Do I need to make any special preparations before receiving Spravato treatment?
Patients are usually advised to avoid eating for at least 2 hours and avoid drinking liquids at least 30 minutes before treatment. It's important to follow the specific instructions given by the healthcare provider.
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