Joseph Raziano, MD
Medical Director
Dr. Raziano is a physician specializing in Emergency Medicine with an M.D. from Tulane University School of Medicine
If you’re considering Spravato® (esketamine) treatment, it’s natural to wonder what the experience will actually be like.
Many patients ask questions such as:
Understanding the process ahead of time can make your first appointment much more comfortable.
At Therapeutic Infusions, Spravato is delivered in a physician-led medical clinic with continuous monitoring, ensuring patients receive treatment in a safe and supportive environment.
If you’re still learning about the therapy itself, you can read more about Spravato treatment in Delaware.
Before beginning treatment, patients complete a consultation with a medical provider.
During this visit, the clinical team reviews:
This evaluation helps determine whether Spravato is appropriate for your condition.
If you are unsure whether you qualify, our guide explaining Spravato eligibility and treatment-resistant depression provides additional details.
On the day of treatment, patients arrive at the clinic and check in with the clinical team.
Preparation typically includes:
Because Spravato can temporarily affect awareness and perception, patients cannot drive themselves home after treatment.
Spravato is administered as a nasal spray under clinical supervision.
Patients self-administer the medication while medical staff observe and guide the process.
The medication is given in several doses spaced a few minutes apart to ensure proper absorption.
Once the medication is administered, patients relax in a comfortable medical recliner while the treatment begins to take effect.
Spravato can temporarily increase blood pressure and cause changes in perception. Because of this, patients must remain under observation after receiving the medication.
During the monitoring period, the clinical team tracks:
Patients typically remain in the clinic for at least two hours, as required by the Spravato REMS safety program.
You can learn more about the safety protocols used at our Spravato clinic with medical monitoring.
Each patient’s experience is slightly different, but many people report sensations such as:
These effects usually begin within 10–15 minutes of administration and gradually fade as the medication wears off.
Most patients remain comfortable and relaxed during the session.
After the monitoring period, patients are discharged once their vital signs have returned to a safe range.
Because Spravato can temporarily impair coordination or awareness:
Many people feel tired afterward, though others report feeling mentally clearer or emotionally lighter.
Spravato treatment follows a structured schedule.
The typical protocol includes:
Weeks 1–4
Two treatments per week.
Weeks 5–8
One treatment per week.
Maintenance phase
Some patients continue treatment every one to two weeks depending on their response.
We will determine the appropriate schedule based on your symptoms and progress.
Many patients want to know whether Spravato treatment is covered by insurance.
Coverage often depends on:
Our clinic assists patients in navigating this process.
You can read more on our page about Spravato insurance coverage.
Know someone who might benefit from Spravato or Ketamine services? Click here to book an appointment
Don’t wait, the start to a happier you starts today. Our office is in Wilmington, Delaware.
Here at Therapeutic Infusions we provide our clients with a safe, relaxed and private environment to feel comfortable working with us.
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M - F 10AM - 6PM
By appointment only - Call for available appointment times